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The widely used Strep-tag technology, consisting of two engineered streptavidin variants, Strep-Tactin and Strep-TactinXT, and two affinity tags, Strep-tagII and Twin-Strep-tag, is not limited in the use of buffers and its high specificity leads to obtaining highly pure proteins

The significance of this observation lies in the fact that VEGFR-2 activation is one of the primary pathways that regulate endothelial cell proliferation and the growth of new blood vessels

Even though modulation of this system offers great promise in the treatment of inflammatory diseases, such as asthma, more work is needed to discover a clinically useful compound